Figure 2
From: A Structurally-Validated Multiple Sequence Alignment of 497 Human Protein Kinase Domains
Representative structures from four different families of atypical kinases showing differences from typical kinase domains. (a) ADCK protein kinase family - ADCK3 (4PED_A); (b) Alpha-type - TRPM7 (1IAJ_A); (c) PI3/PI4 - PIK3CA (4L2Y_A) and (d) RIO-type Ser/Thr kinase family - RIOK1 (4OTP_A). The regions without any structural similarity to the typical kinase domain are colored in yellow, as identified by FATCAT and CEalign (in PyMOL) after aligning to Aurora A (3E5A_A).
