Table 1 Comparison of collagen fibril diameter and interfibrillar spacing of anterior, middle and posterior stroma between Keratoconus and normal corneas, and within the same KC or normal cornea.

From: Collagen fibrils and proteoglycans of peripheral and central stroma of the keratoconus cornea - Ultrastructure and 3D transmission electron tomography

Stromal Zone

Corneal Area

Collagen Fibril Diameter (Mean ± SE)

Interfibrillar spacing (Mean ± SE)

KC (n = sample size)

Normal (n = sample size)

KC (n = sample size)

Normal (n = sample size)

Anterior stroma

Center

27.08 ± 0.08*

(n = 4)

32.13 ± 0.09

(n = 4)

37.89 ± 0.11*

(n = 4)

44.26 ± 0.16

(n = 4)

Periphery

26.76 ± 0.07*, †

(n = 4)

31.43 ± 0.73

(n = 4)

39.23 ± 0.11*,†

(n = 4)

46.89 ± 0.11

(n = 4)

Middle stroma

Center

27.33 ± 0.06*

(n = 4)

30.68 ± 0.08

(n = 4)

38.02 ± 0.08*

(n = 4)

50.93 ± 0.10

(n = 4)

Periphery

27.47 ± 0.06*,†

(n = 4)

31.48 ± 0.06

(n = 4)

38.32 ± 0.08*,†

(n = 4)

49.98 ± 0.12

(n = 4)

Posterior stroma

Center

25.94 ± 0.06*

(n = 4)

30.29 ± 0.08

(n = 4)

35.22 ± 0.11*

(n = 4)

52.23 ± 0.12

(n = 4)

Periphery

27.19 ± 0.07*,†

(n = 4)

30.69 ± 0.10

(n = 4)

37.19 ± 0.11*,†

(n = 4)

54.98 ± 0.22

(n = 4)

Mean

Center

26.82 ± 0.04*

(n = 4)

30.87 ± 0.05

(n = 4)

37.08 ± 0.06*

(n = 4)

49.92 ± 0.08

(n = 4)

Periphery

27.17 ± 0.04*,†

(n = 4)

31.24 ± 0.04

(n = 4)

38.22 ± 0.06*,†

(n = 4)

50.36 ± 0.09

(n = 4)

  1. *Significant difference (p < 0.001) compared with corresponding zone in the normal cornea (Mann-Whitney test).
  2. Significant difference (p < 0.001) compared with central area in the same cornea (KC or normal) (Mann-Whitney test).
  3. SE: Standard error.