Figure 2 | Scientific Reports

Figure 2

From: Dynamic, Simultaneous Concentration Mapping of Multiple MRI Contrast Agents with Dual Contrast - Magnetic Resonance Fingerprinting

Figure 2

In vivo MRI contrast agent relaxivity estimates. T1 enhancement (ΔR1 = 1/T1–1/T10) and T2 enhancement (ΔR2 = 1/T2–1/T20) are plotted against the corresponding ICP-MS measurement of tumor (a,b) Gd (triangles, n = 14) or (c,d) Dy (diamonds, n = 17) concentration. A single sham control is also included (black ‘x’, n = 1). For this calibration step, analyses were performed using only the experiments where the agent of interest was present in the sample. T10,20 were taken as the average of the 10 pre-contrast MRF maps, and T1,2 were from the final (20 minutes post-contrast) MRF maps. A least-squares regression resulted in significant correlations for all experiments (p < 0.001). The slope of the linear fit in each plot is the in vivo magnetic relaxivity ((a,c) r1 and (b,d) r2) of each contrast agent.

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