Figure 3
Non-invasive MRI-based dual agent concentration measurements. (a) Dynamic MRF-based T1 and T2 curves and maps following simultaneous administration of Gd-BOPTA (0.15 mmol/kg) and Dy-DOTA-azide (1.1 mmol/kg). Visible reductions of the tumor T1 and T2 relaxation time constants were observed in both the curves and maps due to tumor uptake of the two contrast agents. (b) Corresponding DC-MRF Gd and Dy concentration curves obtained from the multi-agent relaxation model (Eqs. 2a and 2b) and estimated in vivo relaxivities (from Fig. 2) show visible increases in tumor Gd and Dy concentration.
