Table 1 Attenuation of RV and NYVAC-KC vectors in suckling mice.
From: Recombinant HIV-1 vaccine candidates based on replication-defective flavivirus vector
Age of mice | Construct | Dose(s) tested (log10 ffu/pfu)a | Mortality (%) | LD50 (log10 ffu/pfu) |
|---|---|---|---|---|
2–3 days | RV-Gag | 5, 6 | 0 | N/A |
RV-gp120TM | 5, 6 | 0 | N/A | |
RV-Empty | 5, 6 | 0 | N/A | |
YF17D virus | 0 −1 −2 −3 | 90 71 14 0 | −1.13 | |
NYVAC-KC-gp140 | 8 7 6 | 96 87 33 | 6.3 | |
VC-2b | 2 1 0 | 67 53 18 | 0.04 |
