Table 1 Conversion and enantiomeric excess (ee) values of L-1a-l obtained in the ammonia addition reactions performed under optimal conditionsa.
Substrate | Substituent | PcPAL | [S] (mM) | Time (h) | c (%) | eeL (%) |
|---|---|---|---|---|---|---|
2a | o-CH3 | L256V | 70 | 24 | 91.5 | >99 |
2b | m-CH3 | L134A | 2 | 48 | 26.4 | >99 |
2c | p-CH3 | I460V | 30 | 48 | 59.9 | >99 |
2d* | o-OCH3 | L134A | 10 | 24 | 42.5 | >99 |
2e* | m-OCH3 | L134A | 50 | 48 | 71.0 | >99 |
2f* | p-OCH3 | I460V | 30 | 48 | 19.1 | >99 |
2g* | o-Br | L256V | 70 | 24 | 81.6 | >99 |
2h* | m-Br | I460V | 5 | 24 | 70.1 | 98.3 |
2i* | p-Br | I460V | 10 | 24 | 61.6 | >99 |
2j* | o-CF3 | L256V | 20 | 24 | 73.0 | >99 |
2k | m-CF3 | I460V | 2 | 24 | 77.5 | >99 |
2l* | p-CF3 | I460V | 2 | 48 | 42.2 | >99 |
