Table 2 Outcomes to be assessed by sets of experiments.

From: CIBER-CLAP (CIBERCV Cardioprotection Large Animal Platform): A multicenter preclinical network for testing reproducibility in cardiovascular interventions

Subset

Type of outcomes (n)

Outcomes

A

CMR-based (n = 30)

Myocardial infarct size (%LV); LVEF (%); edema extension (% LV); intramyocardial hemorrhage (presence and extension); microvascular obstruction (presence and extension).

B

Histopathological-based (n = 30)

Myocardial infarct size (%LV);

AAR (% LV area)

Myocardial infarct size (%AAR);

C

Western blot-based (n = 27)

Phosphorylation of Akt, ERK and Stat3 relative to total protein

C

Proteomics

Exploratory analysis

  1. In bold, the primary endpoint for each subset of experiments.
  2. AAR, area at risk; CMR, cardiac magnetic resonance; LV, left ventricular.
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