Figure 4
From: Matrisome-Associated Gene Expression Patterns Correlating with TIMP2 in Cancer
Genes that acquire a positive correlation with TIMP2 in breast/lung tumors are related to the matrisome and a mesenchymal phenotype. (A) Venn diagram of significant tumor specific TIMP2 correlating genes between breast and lung tissue. (B) Pearson’s correlation heatmap for genes associated with ECM remodeling, TGFβ stimulation of fibroblasts and epithelial-mesenchymal transition (EMT) (adapted from pathway analysis using MetaCore). (C) Cytoscape was used to visualize genes that acquire a positive correlation with TIMP2 in tumor tissue as gene ontology networks, with nodes and their color used to depict genes and their correlation change in tumor vs. normal tissue and node size used to depict the correlation score in tumor tissue (no correlation = small node, high correlation = large node). Edges depict reported interactions between nodes (harvested from BioGRID).
