Table 3 A selection of top potential upstream regulators from the significant genes identified, acquired using Ingenuity Pathway Analysis.

From: Matrisome-Associated Gene Expression Patterns Correlating with TIMP2 in Cancer

Upstream regulators of TIMP2 correlates

Regulator

Molecule Type

Gene Hits Breast Lung

TGFB1

Growth Factor

98

89

Alpha catenin

Membrane Receptor

32

31

HRAS

Enzyme

51

41

TWIST1

Transcription Regulator

27

27

WNT3A

Cytokine

28

30

ITGB1

Membrane Receptor

26

23

ERBB2

Kinase

53

44

TGFB2

Growth Factor

21

19

  1. Potential upstream signaling and transcription factors that have been shown to modulate the genes of interest identified as significant following r.test() analysis. Gene hits are the number of significant genes that can be regulated by the identified regulator.
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