Figure 4

Biochemical analysis of plasma from (a) noninfected and (b) L. infantum-infected animals. In both assays, animals were treated with empty scYCWPs (scYCWPs), T6-loaded scYCWPs (scYCWPs + T6), and T6 alone (T6). Miltefosine was used as the standard antileishmanial drug to treat infected mice. Renal, cardiac and hepatic functions were measured through creatinine, CKMB, and alkaline phosphatase, AST and ALT levels, respectively, by UV kinetic determination. All tests were performed in duplicate with three animals per group and the results were shown as mean ± standard error. Significant differences at *p < 0.05, **p < 0.01, ***p < 0.001.