Figure 7
From: Pilot in vivo studies on transcutaneous boiling histotripsy in porcine liver and kidney
Histological analysis of connective tissue structures within volumetric BH lesions in porcine liver. (A) Masson’s trichrome (MT) stained histological section of a liquefied region in the liver. The lobular structure of the liver and the blood vessels and bile ducts are retained within the lesion, although the tissue within each lobule is liquefied. Narrow regions of thermal damage adjacent to the liquefied area (arrows) were observed in some of the lesions as more eosinophilic areas (stained darker pink) that form due to desiccation of cells. The scale bar is 1 mm. (B) Higher magnification histological view of blood vessels within the lesion (arrows). (C) Size distribution of the connective tissue structures (blood vessels and ducts) within intact liver tissue and BH-liquefied lesions. Error bars represent standard deviation; *significant difference between treatment and control group per Student’s t-test at p < 0.05.
