Table 2 CYP2B11 genetic polymorphisms and allele frequencies.
Genetic polymorphism | |||||||||
|---|---|---|---|---|---|---|---|---|---|
#1 | #2 | #3 | #4 | #5 | #6 | #7 | #8 | #9 | |
Positiona | 112817078 | 112828499 | 112832580 | 112832619 | 112832805 | 112832834 | 112832951 | 112833166 | 112833204 |
Reference allele | G | G | TCA | C | TG | G | A | G | G |
Alternate allele | A | A | TCCA | T | CA | A | G | T | C |
dbSNP (v.146) ID | — | rs21894687 | rs852076551 | — | — | — | — | rs850924485 | — |
Location | 5′-enhancer | Exon 7 | 3′UTR | 3′UTR | 3′UTR | 3′UTR | 3′UTR | 3′UTR | 3′UTR |
Protein | — | p.Glu322Glu | — | — | — | — | — | — | — |
cDNA | c.-489_G/A | c.966_G/A | c.1913_TCA/TCCA | c.1952_C/T | c.2137_TG/CA | c.2166_G/A | c.2283_A/G | c.2498_G/T | c.2536_G/C |
Allele frequencies (95% C.I.) | |||||||||
Greyhounds (N = 13) | 0.50 | 0.50 | 0.50 | 0.19 | 0.50 | 0.50 | 0.50 | 1.0 | 0.50 |
(0.30–0.70) | (0.30–0.70) | (0.30–0.70) | (0.09–0.38) | (0.30–0.70) | (0.30–0.70) | (0.30–0.70) | (0.87–1.0) | (0.30–0.70) | |
Other breeds (N = 45) | 0.24 | 0.34 | 0.20 | 0.03 | 0.18 | 0.18 | 0.18 | 0.86 | 0.18 |
(0.17–0.34) | (0.25–0.45) | (0.13–0.29) | (0.01–0.09) | (0.11–0.27) | (0.11–0.27) | (0.11–0.27) | (0.77–0.91) | (0.09–0.23) | |
