Figure 3 | Scientific Reports

Figure 3

From: Lysates of Lactobacillus acidophilus combined with CTLA-4-blocking antibodies enhance antitumor immunity in a mouse colon cancer model

Figure 3

L. acidophilus lysates increased the proportion of Th1 cells and M1 macrophages in the mesenteric lymph nodes. After the 4-week safety evaluation study of L. acidophilus lysates (i.g., Low does lysates, lysates of 5 × 106 CFU L. acidophilus/mouse; High does lysates, lysates of 2 × 107 CFU L. acidophilus/mouse), the cells in mesenteric lymph nodes (mLNs) of each mouse were isolated, respectively stained with a panel of CD3 + CD4 + IFN-γ + (for Th1 cells, A,B) CD11b + F4/80 + CD86 + (for M1 macrophages, D,E), and assessed by flow cytometry. (C,F) The right column charts represent the statistical data shown in the left plot. Control group, 200 μl PBS/mouse (i.g.). Data (n = 10/group) are represented as the mean of each group ± SD.

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