Figure 4 | Scientific Reports

Figure 4

From: Lysates of Lactobacillus acidophilus combined with CTLA-4-blocking antibodies enhance antitumor immunity in a mouse colon cancer model

Figure 4

L. acidophilus lysates inhibited the CD206 expression of RAW 264.7 macrophages and the IL-10 mRNA levels of LPS-activated RAW 264.7 macrophages. (A) L. acidophilus lysates could decrease the mRNA expressed levels of IL-10 in 1 mg/l LPS-activated macrophages, while could not decrease the TNF-α levels (B). The results of flow cytometry suggested that L. acidophilus lysates mediated M2 polarization by inhibition the CD206 receptor on RAW 264.7 macrophages (C). (D) The right column charts represent the statistical data shown in the left plot. The lysate was quantified by the total protein concentration. Data are represented as the mean of each group ± SD.

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