Figure 5 | Scientific Reports

Figure 5

From: The nuclear receptor FXR inhibits Glucagon-Like Peptide-1 secretion in response to microbiota-derived Short-Chain Fatty Acids

Figure 5

FXR deficiency enhances plasma GLP-1 levels in response to colonic SCFA supply in HFD-fed mice. Plasma levels of active GLP-1 were assessed, 1 h after Sitagliptin gavage, in FXR KO mice and their WT littermates after 14 weeks of HFD supplemented or not with the prebiotics ITF. Data are presented as boxplots (from the 25th to 75th percentiles). The whiskers are drawn down to the minimum and up to the maximum. (n = 6 mice per group, except in group FXR KO without ITF n = 4 mice). Two-way ANOVA followed by Bonferronni’s post hoc test. **p < 0.01 ***p < 0.001.

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