Figure 2 | Scientific Reports

Figure 2

From: Oral administration of EP4-selective agonist KAG-308 suppresses mouse knee osteoarthritis development through reduction of chondrocyte hypertrophy and TNF secretion

Figure 2

Effect of oral KAG-308 treatment on synovial tissues in surgically induced mouse knee OA. (a) Representative hematoxylin and eosin (HE) staining of sagittal knee sections from each experimental group 2 wks after OA induction. Inset boxes in the top panels indicate the regions of the bottom panels. Scale bar, 200 µm. (b) Quantification of synovial inflammation in each experimental group (n = 6 in the sham and n = 8 per group in the OA model). Symbols represent individual mice; long and short bars show the mean and SD, respectively. *P < 0.05, **P < 0.005 by ANOVA followed by Tukey’s post hoc test.

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