Table 1 Functional annotation of genes methylation-silenced in primary OS.

From: Epigenetic reprogramming underlies efficacy of DNA demethylation therapy in osteosarcomas

Subtypes

Term

P-value

Genes

Osteosarcoma

Hormone metabolic process

0.018

CYP1B1, STC2, HSD17B8

Estrogen metabolic process

0.032

CYP1B1, HSD17B8

Neurological system process

0.049

CYP1B1, TFAP2A, ADRA1A, MBP

Skeletal system morphogenesis

0.051

HOXC8, HOXA6, TFAP2A

Sensory perception

0.081

CYP1B1, TFAP2A, MBP

Regulation of cell proliferation

0.085

CYP1B1, TNFRSF10D, TFAP2A, ADRA1A, TSPYL5, TES

System process

0.089

DYSF, CYP1B1, TFAP2A, ADRA1A, MBP

Negative regulation of cell proliferation

0.093

CYP1B1, TFAP2A, ADRA1A, TES

  1. DAVID functional annotation analysis was conducted using the genes with TSS200 CGI expressed in mesenchymal stem cell (MSC)/osteoblast (OB) as a background (n = 4,338). Genes methylated (β-value ≥ 0.4) in more than 5 of 28 primary OS tissues (M0) are listed.
Back to article page