Figure 1
Effects of rolipram treatments on the survival rate (%) of septic shock mice within 7 days. (A) Male C57BL/6 mice were injected with rolipram (10 mg/kg, i.p.) 6 hrs before E. coli injection (1.5 × 108 CFU, i.p.), rolipram group: n = 10, E.coli group: n = 20, rolipram + E.coli group: n = 20. (B) Male C57BL/6 mice were injected with rolipram (15 mg/kg, i.p.) 6 hrs after CLP surgery, sham group: n = 10, CLP group: n = 25, CLP + rolipram group: n = 26. (C) Male C57BL/6 mice were injected with rolipram (10 mg/kg i.p.) 1 hr before LPS injection (15 mg/kg i.p.), rolipram group: n = 10, LPS group: n = 37, rolipram + LPS group: n = 32. (D) Male C57BL/6 mice were injected with different doses of rolipram (1 mg/kg, 5 mg/kg, and 10 mg/kg, i.p.) 1 hr before LPS injection. Survival of mice was monitored for 7 days. Kaplan-Meier analysis, followed by a log-rank test, was used for survival time analysis. *Represents p < 0.05 in treatments vs. LPS groups.
