Figure 2 | Scientific Reports

Figure 2

From: Concomitant febuxostat enhances methotrexate-induced hepatotoxicity by inhibiting breast cancer resistance protein

Figure 2

Serum MTX concentrations at 24 h (a), 48 h (b), and 72 h (c) following HDMTX therapy in patients with (72 cycles) and without (72 cycles) receiving FBX. The box and whisker plot represent the median, first and third quartiles, and minimum and maximum values of serum MTX concentration. The open circles represent outliers that are >1.5-times the interquartile range from a quartile. The risk limit values of serum MTX concentration (>10 μmol/L at 24 h, >1 μmol/L at 48 h, and >0.1 μmol/L at 72 h) after MTX administration are indicated by the dotted horizontal lines. Statistical analyses were performed using Mann-Whitney U-test.FBX: febuxostat, MTX: methotrexate.

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