Table 1 Survey results, comparing SRH versus conventional tissue processing and staining.
From: Intraoperative assessment of skull base tumors using stimulated Raman scattering microscopy
|  | Neuropathologist 1 | Neuropathologist 2 | Neuropathologist 3 | Interpathologist reliability (κF) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
SRH | H&E frozen | H&E FFPE | SRH | H&E frozen | H&E FFPE | SRH | H&E frozen | H&E FFPE | SRH | H&E frozen | H&E FFPE | |
Neoplasm Description: | ||||||||||||
Percent Agreement | 88% | 88% | 88% | 75% | 88% | 81% | 75% | 75% | 75% | Â | Â | Â |
Concordance (κc) | 0.78 | 0.80 | 0.80 | 0.52 | 0.78 | 0.66 | 0.61 | 0.56 | 0.59 | 0.48 | 0.78 | 0.63 |
Relative Accuracy | 100% | — | — | 92% | — | — | 100% | — | — |  |  |  |
Architectural Pattern: | ||||||||||||
Percent Agreement | 75% | 75% | 75% | 69% | 88% | 81% | 44% | 56% | 50% | Â | Â | Â |
Concordance (κc) | 0.64 | 0.65 | 0.65 | 0.58 | 0.83 | 0.74 | 0.34 | 0.48 | 0.43 | 0.28 | 0.38 | 0.41 |
Relative Accuracy | 100% | — | — | 85% | — | — | 88% | — | — |  |  |  |
Nuclear Shape: | ||||||||||||
Percent Agreement | 94% | 100% | 94% | 94% | 94% | 94% | 88% | 94% | 94% | Â | Â | Â |
Concordance (κc) | 0.87 | 1.00 | 0.86 | 0.86 | 0.86 | 0.86 | 0.73 | 0.86 | 0.86 | 0.64 | 0.91 | 0.82 |
Relative Accuracy | 100% | — | — | 100% | — | — | 93% | — | — |  |  |  |
Differential: | ||||||||||||
Percent Agreement | 94% | 100% | 100% | 94% | 100% | 100% | 94% | 100% | 100% | Â | Â | Â |
Concordance (κc) | 0.90 | 1.00 | 1.00 | 0.90 | 1.00 | 1.00 | 0.90 | 1.00 | 1.00 | — | — | — |
Relative Accuracy | 94% | — | — | 94% | — | — | 94% | — | — |  |  |  |
Final Diagnosis: | ||||||||||||
Percent Agreement | 88% | 94% | 100% | 75% | 94% | 81% | 81% | 100% | 94% | Â | Â | Â |
Concordance (κc) | 0.80 | 0.90 | 1.00 | 0.61 | 0.90 | 0.68 | 0.66 | 1.00 | 0.90 | 0.57 | 0.87 | 0.79 |
Relative Accuracy | 88% | — | — | 85% | — | — | 87% | — | — |  |  |  |
Confidence score | 3.13 | 3.50 | 3.50 | 2.31 | 2.81 | 3.31 | 2.94 | 3.63 | 3.56 | Â | Â | Â |
