Table 1 Range of daily variation within subjects.

From: Synchronization of the Normal Human Peripheral Immune System: A Comprehensive Circadian Systems Immunology Analysis

Parameter

Minimum

Maximum

Mean

ICC

WBC (103/μL)

0.90

3.20

1.64

83%

Platelets (103/μL)

18.00

97.00

42.89

91%

Neutrophils (103/μL)

6.00

23.40

11.09

8%

Lymphocytes (103/μL)

4.40

27.60

10.34

63%

Monocytes (103/μL)

1.40

5.70

2.58

76%

Eosinophils (103/μL)

0.50

1.50

1.01

83%

Basophils (103/μL)

0.20

0.40

0.28

68%

Granulocye % of Leukocytes

6.60

18.30

11.94

67%

Lymphocyte % of Leukocytes

6.30

18.40

11.74

67%

B cell % of Lymphocyte

1.57

7.17

3.35

91%

DC % of Lymphocyte

0.10

1.43

0.44

22%

Monocyte % of Lymphocyte

2.30

8.00

5.16

70%

Classical % of Monocytes

5.90

13.20

9.48

48%

Nonclassical % of Monocytes

5.90

13.20

9.49

48%

NK % of Lymphocyte

1.29

16.16

4.43

71%

CD56dim % of NK

1.70

11.60

5.96

67%

CD56bright % of NK

1.64

11.57

5.95

67%

NKT % of Lymphocyte

0.24

2.94

0.91

92%

CD4 Tconv % of Lymphocyte

1.70

17.00

6.98

87%

Naive % of CD4 Tconv

3.40

7.80

5.90

98%

Tem % of CD4 Tconv

1.25

5.00

2.44

97%

Tcm % of CD4 Tconv

1.09

6.00

4.45

98%

Temra % of CD4 Tconv

0.03

5.70

0.93

98%

Treg % of Lymphocyte

0.42

1.54

0.91

49%

CD8 T cell % of Lymphocyte

0.88

7.00

2.46

92%

Naive % of CD8 T cells

7.00

20.30

11.16

86%

Tem % of CD8 T cells

3.48

13.10

8.80

88%

Tcm % of CD8 T cells

1.71

21.00

6.72

89%

Temra % of CD8 Tcells

0.90

19.30

5.66

96%

CD4-CD8- T cell % of Lymph.

0.30

1.45

0.80

81%

CD4+CD8+ T cell % of Lymph.

0.10

2.55

0.65

89%

Unidentified % of Lymphocyte

2.20

11.70

4.32

83%

Serum IFNγ

1.39

7.47

3.37

94%

Serum IL 12

0.95

2.76

1.57

96%

Serum IL 2

0.40

2.82

1.21

97%

Serum IL 4

4.37

28.15

12.75

97%

Serum IL 6

0.58

3.27

1.83

99%

Plasma IFNγ

0.87

8.61

3.36

96%

Plasma IL 12

0.77

4.37

2.19

95%

Plasma IL 2

0.37

2.34

1.24

98%

Plasma IL 4

7.26

46.11

23.54

80%

Plasma IL 6

0.73

5.08

2.20

97%

Serum sIL 2Ra

103.61

326.00

183.39

94%

Serum sIL 4 R

111.00

1566.00

515.78

72%

Serum sIL 6 R

2544.00

17085.00

7597.44

86%

Plasma sIL 2Ra

72.31

306.00

173.95

91%

Plasma sIL 4 R

96.00

1278.00

383.22

84%

Plasma sIL 6 R

4223.00

12112.00

6578.33

84%

cortisol

8.82

25.10

12.97

39%

  1. For each component, data presented are minimum, maximum and mean of the ranges found across all time points from each of the 9 subjects. Units: Cell populations (%), soluble factors (pg/mL). Abbreviations: DC = dendritic cell; NK = natural killer cell; Tconv = Conventional T-cell; Tem = effector memory T-cell; Tcm = central memory T-cell; ICC = intraclass correlation.
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