Figure 1
Ginsenoside Rb1 inhibited INa in a concentration-dependent manner. (a) Representative current recordings of INa in the absence and presence of Rb1. (b) The current-voltage relationship of INa (n = 10, *p < 0.05 vs. control, #p < 0.05 vs. 1 μmol/L Rb1, !p < 0.05 vs. 5 μmol/L Rb1, &p < 0.05 vs. 10 μmol/L Rb1). (c) The dose-response relationship of INa. (d) The steady-state activation and inactivation curves of INa in the absence and presence of 20 μmol/L Rb1. (e) Representative current recordings of INa elicited by the pulse in steady-state inactivation curves in the absence and presence of 20 μmol/L Rb1. (f) INa recordings in control conditions, upon addition of 20 μmol/L Rb1, and after Rb1 washout. (g) Summary of the data in panel f (n = 11, **p < 0.01 vs. control, ##p < 0.01 vs. 20 μmol/L Rb1).
