Table 1 Effects of Rb1 (20, 40, and 80 μmol/L) on action potentials.

From: Ginsenoside Rb1 exerts antiarrhythmic effects by inhibiting INa and ICaL in rabbit ventricular myocytes

 

Control

Rb1 (μmol/L)

20

40

80

RMP (mV)

76.9 ± 2.4

77.0 ± 2.1

76.8 ± 2.3

76.9 ± 2.8

APA (mV)

132.8 ± 4.6

129.7 ± 6.8

126.0 ± 6.2*

118.7 ± 4.9**##†

Vmax (V/s)

197.0 ± 8.6

194.7 ± 7.2

189.0 ± 9.0**##

178.1 ± 10.4##††

APD50

219.9 ± 11.5

216.0 ± 14.5

195.2 ± 18.6**#

176.4 ± 15.9**##†

APD90

242.6 ± 15.0

237.6 ± 19.4

215.6 ± 19.4**##

189.4 ± 20.8##††

  1. Note: RMP = resting membrane potential; APA = action potential amplitude; Vmax = maximum upstroke velocity; APD50 = action potential duration at 50% repolarization; APD90 = action potential duration at 90% repolarization. The data are expressed as the mean ± SD (n = 10, stimulation frequency = 1 Hz). **P < 0.01 vs. Control, *P < 0.05 vs. Control, ##P < 0.01 vs. 20 μmol/L, #P < 0.05 vs. 20 μmol/L, †P < 0.05 vs. 40 μmol/L, ††P < 0.01 vs. 40 μmol/L.
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