Figure 4
From: NLRP6 self-assembles into a linear molecular platform following LPS binding and ATP stimulation
Higher molecular weight NLRP6 oligomers. (a) Comparison of representative experimentally determined class averages (below) to 2D reprojections of the 3D-reconstructed hexamer volume (above). (b) Model fitting of NLRP6 hexamer with the NLRP6 dimer model and a cartoon showing a 120° anti-clock deflection. (c) Representative particles of NLRP6 octamer, decamer, hexadecamer and octadecamer. An obvious shrinked link exists between each two neighboring dimer units. See also Supplementary Fig. 4, Supplementary Movie 2.
