Table 4 Multivariate analyses evaluating late grade 2 or higher toxicities in 421 patients after salvage radiotherapy.

From: Impact of advanced radiotherapy techniques and dose intensification on toxicity of salvage radiotherapy after radical prostatectomy

 

Gastrointestinal toxicity

Genitourinary toxicity

HR (95% CI)

p-value

HR (95% CI)

p-value

Age > 70

2.3 (0.68–8.0)

0.18

0.89 (0.44–1.8)

0.75

Time between RP and SRT ≤12 M

1.8 (0.58–5.3)

0.32

1.4 (0.68–2.7)

0.38

SRT dose (EQD2) ≥68 Gy

2.8 (0.90–8.6)

0.075

3.1 (1.3–7.4)

0.012

SRT fraction dose >2 Gy

1.1 (0.26–4.6)

0.91

1.1 (0.49–2.4)

0.85

Non-use of advanced RT techniques*

3.1 (1.8–5.4)

<0.001

0.89 (0.61–1.3)

0.55

Use of WPRT

7.6 (1.0–56)

0.048

0.75 (0.10–6.1)

0.79

Use of ADT

0.90 (0.19–4.1)

0.89

0.89 (0.38–2.1)

0.79

  1. HR hazard ratio, 95% CI 95% confidence interval, SRT salvage radiotherapy,
  2. RP radical prostatectomy, EQD2 equivalent dose in 2-Gy fractions,
  3. IMRT intensity-modulated radiation therapy, IGRT image-guided radiation therapy,
  4. WPRT whole-pelvic radiotherapy, ADT androgen deprivation therapy.
  5. *Advanced RT techniques means IMRT or IGRT or both.
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