Table 2 Clinical Characteristics of High-Tension Glaucoma (HTG) and Normal-Tension Glaucoma (NTG).

From: Exploring the Novel Susceptibility Gene Variants for Primary Open-Angle Glaucoma in East Asian Cohorts: The GLAU-GENDISK Study

 

Primary Cohort (Korea)

Replication Cohort #1 (Korea)

Replication Cohort #2 (Japan)

HTG (n = 55)

NTG (n = 254)

P-value

HTG (n = 61)

NTG (n = 249)

P-value

HTG (n = 119)

NTG (n = 446)

P-value

Age, y

54.1 ± 15.3

56.5 ± 13.2

0.29*

54.7 ± 15.6

54.7 ± 13.0

0.99*

64.1 ± 10.7

64.4 ± 12.0

0.78*

Female, %

36.4

53.1

0.035†

39.3

46.6

0.38†

36.1

47.5

0.034†

Baseline IOP, mmHg

24.8 ± 8.1

15.2 ± 3.2

<0.001*

23.3 ± 5.3

15.2 ± 2.9

<0.001*

27.5 ± 6.9

16.1 ± 2.7

<0.001*

CCT, μm

545.0 ± 30.7

532.0 ± 34.3

0.010*

547.0 ± 30.4

534.0 ± 33.9

0.010*

520.0 ± 35.5

509.3 ± 34.4

0.012*

AXL, mm

24.7 ± 1.6

24.5 ± 1.6

0.47*

24.9 ± 2.4

24.8 ± 1.7

0.88*

25.4 ± 1.8

25.2 ± 1.8

0.47*

Average RNFLT, μm

64.0 ± 11.6

70.9 ± 11.4

<0.001*

63.6 ± 14.9

70.8 ± 12.1

0.002*

76.8 ± 13.2

80.1 ± 13.9

0.051*

MD, dB

−15.2 ± 10.1

−8.8 ± 6.9

<0.001*

−13.6 ± 9.0

−7.0 ± 6.1

<0.001*

−14.8 ± 9.1

−13.1 ± 8.5

0.12*

  1. HTG: high-tension glaucoma, NTG: normal-tension glaucoma, IOP: intraocular pressure, CCT: central corneal thickness, AXL: axial length, RNFL: retinal nerve fiber layer, MD: mean deviation. Mean ± standard deviation, *Comparison performed using Student’s t-test, †Comparison performed using chi-square test.
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