Table 3 Association of rs116121322 in LRRC27 with Primary Open-Angle Glaucoma.

From: Exploring the Novel Susceptibility Gene Variants for Primary Open-Angle Glaucoma in East Asian Cohorts: The GLAU-GENDISK Study

rsID

Gene

Chr

AA change

Alleles

Population

Stage

MAF Case

MAF Control

OR (95% CI)

P-value

rs116121322

LRRC27

10

V189I

G > A

POAG

Primary (KOR)

0.00971

0.00037

29.85 (7.99–111.59)

2.2E-06

     

Replication#1 (KOR)

0.00647

0.00054

10.40 (2.82–38.32)

0.002

     

Replication#2 (JPN)

0.00090

0.00241

0.43 (0.05–3.78)

0.44

     

Combined (KOR)

0.00809

0.00046

17.79(7.19–44.01)

1.6E-07*

     

Meta-analysis (KOR + JPN)

  

10.28

1.4E-07*

     

NTG

Primary (KOR)

0.00787

0.00037

18.75 (4.47–78.69)

0.0004

     

Replication#1 (KOR)

0.00604

0.00054

9.86 (2.35–41.31)

0.007

     

Replication#2 (JPN)

0.00135

0.00241

0.67 (0.08-5.88)

0.72

     

Combined (KOR)

0.00697

0.00046

14.13 (5.21–38.37)

2.3E-05*

     

HTG

Primary (KOR)

0.01818

0.00037

76.78 (13.32–442.58)

0.0004

     

Replication#1 (KOR)

0.00820

0.00054

15.18 (1.77–130.02)

0.06

     

Replication#2 (JPN)

0.00000

0.00241

NA

NA

     

Combined (KOR)

0.01293

0.00046

28.91 (7.85–106.46)

3.8E-04*

  1. Chr: chromosome, AA: amino acid, MAF: minor allele frequency, POAG: primary open-angle glaucoma (i.e., NTG OAHTG), NTG: normal-tension glaucoma, HTG: high-tension glaucoma, OR: odds ratio, KOR: Korea, JPN: Japan, NA: not applicable. *P-values adjusted by Benjamini-Hochberg method to compensate for multiple comparison.
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