Figure 3
Determination Gadofluorine P kinetics by mass spectrometry imaging. (A) Gadofluorine P detection at baseline, 15, 30, 45 and 60 minutes following i.v. injection by MALDI MSI. Signal is shown as % of maximum intensity, not being fully quantitative. Representative images of one animal per time point is shown. Per time point n = 3 mice were investigated. (B) Elemental LA-ICP-MS of Gd(III) shows gadolinium accumulation at the aortic root (arrows) with a spatial resolution of 15 μm (top panel: white light microscopy image, bottom panel: LA-ICP-MS) and only minor Gd(III) accumulation in the adjacent myocardium (asterisk). Gd(III) concentrations peaked at 30 minutes post injection. Data shown as Mean ± SEM.
