Figure 4
Monitoring of atherosclerosis formation by combined MR and mass spectrometry imaging. (A) R1 values from MR analyses of atherosclerotic lesions at the aortic root over the course of atherosclerotic plaque progression were corroborated by Gd(III) detection in corresponding lesions by LA-ICP-MS (B). The course of Gadofluorine P accumulation was accompanied by an increase in Mean Chromogen Red Intensity on Elastica van Gieson stains (C), indicative of increased ECM presence in atherosclerotic lesions. Scatter dot plots show Mean ± SEM, n = 3–6 mice per time point.
