Figure 3

Immune-regulatory functions of iPSC-TECs. (a) Schematic overview of iPSC-TEC and skin transplantation. Timeline shows the procedure of recipient preconditioning and skin transplantation. (b) Kaplan-Meier curves for each skin graft are shown with p-value (B6 skin). Solid line, survival of each skin graft transplanted to iPSC-TEC recipients (n = 6). Dotted line graft survival in MEF (control cell) aggregate recipients (n = 6). (*p < 0.05, generalized Wilcoxon test) (c) Percent graft size of B6 and BALB/c skin after transplantation with error bars on each day of size measurement. (left) iPSC-TEC aggregates pre-transplanted group, (right) MEF aggregates pre-transplanted group. Statistical significance was evaluated when n ≥ 3 at each time point. (*p < 0.05, two-tailed Student’s t-test).