Figure 1 | Scientific Reports

Figure 1

From: Blockade of Arginine Vasopressin receptors prevents blood-brain barrier breakdown in Experimental Autoimmune Encephalomyelitis

Figure 1

AVP deficiency by NIL surgery significantly attenuated EAE-induced blood brain barrier hyper-permeability to Evans blue. Six rats of every group were randomly assigned for the evaluation of BBB permeability using Evans blue extravasation assay. BBB permeability in NIL brain (a) and spinal cord (b) tissues was significantly decreased compared to the SHAM group. (c) Representative Evans blue extravasation in the brain and spinal cord of the intact control (IC), simulated operated animals immunized for Experimental Autoimmune Encephalomyelitis (SHAM) and animals with Neurointermediate Lobectomy of the pituitary plus EAE (NIL). Data represents mean ± SD, ****P < 0.0001, using a one-way ANOVA and Tukey´s post hoc test.

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