Figure 6
From: BAD sensitizes breast cancer cells to docetaxel with increased mitotic arrest and necroptosis
BAD-mediated mitotic arrest is downstream of AMPK. (a) MDA-MB-231 cells stably expressing vector or BAD were treated with 125 nM docetaxel for 48 hours prior to high-resolution respirometry. One-way ANOVA with Dunnett’s post-hoc test; n = 3. (b) Cells were treated with 125 nM docetaxel for 16, 24, or 48 hours. DMSO control treatment was for 48 hours. Right: Quantification of pAMPK-Thr172 levels over AMPK total protein were normalized to tubulin. One-way ANOVA with Dunnett’s post-hoc test; n = 3.
