Table 2 Maternal lipid concentrations and gestational change in lipid concentrations by BMI group.

From: Maternal preconception lipid profile and gestational lipid changes in relation to birthweight outcomes

 

Overall, N = 575

Preconception BMI <25 kg/m2, N = 335

Preconception BMI ≥25 kg/m2, N = 240

P value

Preconception lipid concentrationa (mg/dL)

   Total cholesterol

165.4 (28.6)

161.4 (27.3)

170.9 (29.5)

<0.0001

   LDL-C

90.7 (25.2)

87.0 (22.8)

95.9 (27.5)

<0.0001

   HDL-C

52.0 (12.3)

55.2 (12.3)

47.6 (10.7)

<0.0001

   Triglyceride

114.1 (60.0)

97.2 (41.8)

137.8 (72.4)

<0.0001

28-week lipid concentrationb (mg/dL)

   Total cholesterol

239.8 (41.7)

243.3 (42.6)

234.9 (39.9)

0.020

   LDL-C

130.7 (38.3)

134.0 (38.4)

126.1 (37.9)

0.020

   HDL-C

64.5 (15.0)

66.3 (14.9)

62.1 (15.0)

0.002

   HDL-C at 20 weeksc (HDL-C peak)

66.6 (14.9)

69.0 (14.6)

63.4 (14.7)

<0.0001

   Triglyceride

223.2 (72.8)

215.7 (71.2)

233.3 (74.5)

0.006

Change in lipid concentration, preconception to 28 weeks gestation (mg/dL)

   Total cholesterol

74.1 (38.4)

81.7 (36.7)

63.5 (38.2)

<0.0001

   LDL-C

39.7 (34.7)

46.8 (33.8)

29.8 (33.5)

<0.0001

   HDL-C

12.7 (11.4)

11.1 (11.4)

14.8 (11.1)

0.0002

   HDL-C, 0 to 20 weeks (HDL-C peak)

14.7 (10.8)

13.8 (11.0)

15.9 (10.4)

0.027

   Triglyceride

109.1 (67.1)

118.3 (65.7)

96.3 (67.0)

0.0002

  1. Maternal lipid concentrations at preconception, at 28 weeks gestation, and the calculated change in lipid concentration from preconception to 28 weeks are presented for the overall cohort and by BMI group (<25 v. ≥25 kg/m2), limited to n = 575 women with singleton birth between 22–43 weeks gestation and birthweight and maternal preconception BMI available. Mean (SD) presented for all lipids. P value for significant difference in lipid concentration or lipid change by BMI group (one-way ANOVA) is presented.
  2. BMI, body mass index; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol.
  3. aMissing lipid values, preconception: Total cholesterol and triglyceride, n = 9 overall, n = 4 BMI <25, n = 5 BMI ≥25; LDL-C, n = 16 overall, n = 7 BMI <25, n = 9 BMI ≥25; HDL-C, n = 13 overall, n = 7 BMI <25, n = 6 BMI ≥25;
  4. bMissing lipid values, 28 weeks, for all lipids: n = 38 overall, n = 23 BMI <25, n = 15 BMI ≥25.
  5. cMissing HDL-C values, 20 weeks: n = 36 overall, n = 23 BMI <25, n = 13 BMI ≥25.
Back to article page