Figure 4

Simulation of RVD treated with anti-oxidant (Vitamins C and E): Simulation of RVD with anti-oxidant administration results in a decrease in factors involved in oxidative stress, inflammation, fibrosis, and MV rarefaction compared to simulation of RVD with no treatment, while increasing factors involved in angiogenic signaling and improved endothelial function. Despite an overall beneficial profile, anti-oxidant administration was unable to combat mild ischemia, NADPH oxidase, Ang II, ROS scavenging, or Ox-LDL, though there was no change in activity of these variables. Names of the factors are identified in the y axis and indicated in green when active and are depicted in gray when inactive (A). Variables that were inactive after anti-oxidant administration simulation compared to untreated RVD control are depicted in red, and factors that activated are depicted in blue (B). The first column in (A,B) depicts the initial steady state condition at which time the simulation has been initiated but has not yet produced changes.