Figure 4
From: Large-scale Analyses of Disease Biomarkers and Apremilast Pharmacodynamic Effects
Systematic literature review of KLK-7 and phenotypes. Columns of panel A and B are aligned and labeled in panel B. (A) The highest HPO parent class(es) for each phenotype that co-occurred with KLK-7 in Medline abstracts. The association frequency of KLK-7 with the abnormality of the integument is the second highest behind neoplasm; (B) Specificity score for each unique gene-phenotype pairing extracted from Medline abstracts based on sentence level co-occurrence of KLK-7 and phenotype terms. Size of a circle indicates the square root of the number of publications covering a gene-phenotype pairing. Top 3 conditions with the highest specificity all of the skin-related diseases.
