Table 2 Beta coefficients, p-values and R2 values in linear regression models evaluating correlation between PASI total score and protein expression in PSOR patients.
From: Large-scale Analyses of Disease Biomarkers and Apremilast Pharmacodynamic Effects
PASI | Baseline | Week 4 | Week 16 | |||
|---|---|---|---|---|---|---|
Analyte | beta | p | beta | p | beta | p |
IL-17A | 3.46 | 2.73E-08 | 3.85 | 4.81E-07 | 4.85 | 4.01E-08 |
gender | 0.98 | 0.3715 | 2.30 | 0.0705 | 1.57 | 0.29 |
age | −0.06 | 0.3282 | 0.06 | 0.9929 | 0.07 | 0.9933 |
R2 | 0.29 | 0.32 | 0.35 | |||
p(F-test) | 2.47E-07 | 1.20E-06 | 1.54E-07 | |||
KLK-7 | 3.36 | 1.64E-07 | 3.52 | 1.56E-05 | 5.04 | 6.32E-09 |
gender | 0.18 | 0.88 | 1.55 | 0.2452 | 1.38 | 0.34 |
age | −0.02 | 0.5764 | 0.06 | 0.9929 | 0.05 | 0.9933 |
R2 | 0.26 | 0.26 | 0.38 | |||
p(F-test) | 1.34E-06 | 3.21E-05 | 2.65E-08 | |||
Additive IL17A + KLK7 | ||||||
IL17A | 2.40 | 3.97E-05 | 1.63 | 7.91E-3 | 1.26 | 3.73E-2 |
KLK7 | 2.06 | 5.11E-4 | 1.99 | 1.64E-3 | 1.85 | 2.31E-3 |
gender | 0.31 | 0.76 | 0.06 | 0.96 | −0.47 | 0.67 |
age | −0.04 | 0.3264 | 0.01 | 0.7399 | 0.01 | 0.77 |
R2 | 0.35 | 0.26 | 0.20 | |||
p(F-test) | 2.63E-11 | 1.36E-06 | 4.75E-05 | |||
