Table 3 Beta coefficients, p-values and R2 values in linear regression models evaluating correlation between ASDAS score and protein production in AS patients.
From: Large-scale Analyses of Disease Biomarkers and Apremilast Pharmacodynamic Effects
ASDAS | Baseline | Week 4 | Week 16 | |||
|---|---|---|---|---|---|---|
Analyte | beta | p | beta | p | beta | p |
Univariate IL-6 | 0.43 | 3.66E-18 | 0.45 | 5.13E-14 | 0.48 | 1.45E-13 |
gender | 0.05 | 0.5895 | −0.09 | 0.6804 | −0.07 | 0.6160 |
age | −0.10 | 0.1598 | −0.16 | 0.0921 | −0.08 | 0.9066 |
R2 | 0.30 | 0.25 | 0.23 | |||
p(F-test) | 3.49E-18 | 2.64E-13 | 4.25E-12 | |||
Univariate LRG1 | 0.53 | 2.56E-32 | 0.47 | 1.14E-16 | 0.5 | 4.15E-15 |
gender | 0.27 | 0.0575 | 0.14 | 0.6804 | 0.18 | 0.5291 |
age | −0.13 | 0.1239 | −0.17 | 0.0921 | −0.03 | 0.9066 |
R2 | 0.46 | 0.29 | 0.26 | |||
p(F-test) | 3.79E-32 | 6.81E-16 | 1.35E-13 | |||
Additive IL6 + LRG1 | ||||||
IL6 | 0.14 | 2.75E-03 | 0.24 | 2.52E-04 | 0.26 | 3.65E-04 |
LRG1 | 0.44 | 1.84E-18 | 0.32 | 2.30E-07 | 0.33 | 4.50E-06 |
gender | 0.21 | 0.0143 | 0.03 | 0.8136 | 0.05 | 0.6603 |
age | −0.12 | 0.0432 | −0.16 | 0.0373 | −0.05 | 0.51 |
R2 | 0.49 | 0.33 | 0.29 | |||
p(F-test) | 1.45E-38 | 4.88E-20 | 1.28E-17 | |||
