Figure 1 | Scientific Reports

Figure 1

From: Precise safety pharmacology studies of lapatinib for onco-cardiology assessed using in vivo canine models

Figure 1

Time courses of change in the heart rate (HR), mean blood pressure (MBP), cardiac output (CO), total peripheral vascular resistance (TPR), maximum upstroke velocity of the left ventricular pressure (peak +dP/dt), maximum downstroke velocity of the left ventricular pressure (peak −dP/dt) and left ventricular end-diastolic pressure (LVEDP) after the administration of lapatinib. Data are presented as mean ± SEM (n = 5). Closed symbols represent significant differences from the corresponding pre-drug basal control values (C) by p < 0.05.

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