Table 1 The effects of lapatinib on the variables of the echocardiogram and left ventricular pressure.
Cardiac cycle | Variables | Control | 0.3 mg/kg | 3 mg/kg | P value | |||
|---|---|---|---|---|---|---|---|---|
30 min | 30 min | 60 min | ||||||
Dimensions | End-diastole | LVDd | (mm) | 25 ± 1 | 24 ± 1 | 23 ± 1 | 24 ± 1 | 0.54 |
LVEDV | (mL) | 22 ± 3 | 21 ± 2 | 19 ± 2 | 20 ± 2 | 0.52 | ||
End-systole | LVDs | (mm) | 17 ± 1 | 16 ± 1 | 16 ± 1 | 16 ± 1 | 0.39 | |
LVESV | (mL) | 9 ± 1 | 8 ± 1 | 7 ± 1 | 9 ± 2 | 0.24 | ||
Systolic function | Ejection period | EF (Teich) | (%) | 62 ± 2 | 61 ± 2 | 63 ± 3 | 62 ± 2 | 0.18 |
%FS | (%) | 31 ± 2 | 31 ± 1 | 33 ± 3 | 32 ± 2 | 0.27 | ||
Diastolic function | Passive filling | E/A | 1.27 ± 0.22 | 1.28 ± 0.25 | 1.29 ± 0.27 | 1.10 ± 0.19 | 0.52 | |
E′ | (m/s) | 0.064 ± 0.011 | 0.064 ± 0.013 | 0.060 ± 0.013 | 0.064 ± 0.012 | 0.87 | ||
E/E′ | 7.77 ± 0.80 | 7.70 ± 0.79 | 8.45 ± 0.96 | 7.25 ± 0.50 | 0.42 | |||
EDPVR | (mmHg/mL) | 0.46 ± 0.07 | 0.59 ± 0.08 | 0.68 ± 0.19 | 0.72 ± 0.17 | 0.14 | ||
Active relaxation | IRT | (ms) | 89.9 ± 6.6 | 93.0 ± 8.6 | 99.7 ± 9.7 | 114.5 ± 6.8 | 0.17 | |
