Figure 2

The definition and a representative image of measurement of the CSI irregularity index. (A) The hatched area between the choroidoscleral interface (CSI) on optical coherence tomography and its best-fit spherocylinder demonstrate the concept of the CSI irregularity index, which is defined as the weighted sum of differences at each measured point between the CSI on optical coherence tomographic image and its best-fit spherocylinder. (B) Before importing images into Matlab software, the CSI was manually delineated. (C) After removing background noise with the thresholding filter in Matlab software, the contour of the CSI was subsequently extracted. (D) The polynomial curve was used for curve fitting with the Curve Fitting Tool in Matlab software. The order of polynomial function was determined to identify the best approximation to the shape of the CSI. The Polyfit function was used to fit the coordinates via the least squares principle. CSI irregularity index = 12.6665.