Figure 1

Overview of the flowchart. (A) mRNA and miRNA expression profiles for NSE and SE. (B) Predicted TF/miRNA-target pairs. (C) Subtype-specific regulation pairs. (D) Feed-forward loop (FFL) models. (E) Subtype-specific regulatory networks and hub detection. (Microsoft Visio 2016; RStudio version 1.1.383, https://rstudio.com/; Cytoscape version 3.7.1, https://cytoscape.org/).