Figure 5 | Scientific Reports

Figure 5

From: Potent inhibition of HIV replication in primary human cells by novel synthetic polyketides inspired by Aureothin

Figure 5

Compound #7 potently inhibits multiple HIV genotypes. PBMCs were exposed to the indicated clinical virus isolates and serial concentrations of compound #7 and (a) half maximal (IC50) and (b) 90% (IC90) HIV-inhibitory concentrations were determined. Clinical isolates represented the following HIV genotypes: HIV-1MMVP899-87: HIV-type 1, Major group; HIV-1OMVP5180-91: HIV-type 1, Outlier group; HIV-2MVP10668-93: HIV-type 2; HIV-1V13-03413B: HIV-type 1, Major group/B-clade, isolate with multiple drug-resistance mutations8. Depicted are the means of three independent experiments with biological triplicates (n = 3; m = 3) and standard deviations (SD).

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