Table 2 Correlation between (a) Expanded Disability Status Scale (EDSS), Fatigue Scale for Motor and Cognitive functions (FSMC) or disease duration and effective connectivity (EC) values between baseline (t1 = 0 months) and the last follow-up (t5 = 12 months) calculated as ΔEC = EC [t5] − EC [t1]. Higher ΔEC values correspond to more rapidly increasing EC. Only significant directed connections from the deep grey matter nuclei (DGMN), frontal, prefrontal and temporal regions were considered in the correlation analyses between ΔEC and the three clinical parameters.
Correlation with … | ΔEC from … | To … | CBN analysis | TPDC analysis | ||
|---|---|---|---|---|---|---|
Pearson’s r | p-value(a) | Pearson’s r | p-value(a) | |||
EDSS | frontal | prefrontal | −0.58 | 0.0003 | −0.71 | 0.0004 |
frontal | cerebellum | −0.52 | 0.0007 | −0.65 | 0.0002 | |
FSMC | frontal | cerebellum | −0.54 | 0.0005 | −0.62 | 0.0080 |
Disease duration | frontal | prefrontal | −0.50 | 0.0008 | −0.58 | 0.0003 |
frontal | cerebellum | −0.69 | 0.0006 | −0.77 | 0.0008 | |
DGMN | prefrontal | 0.62 | 0.0005 | 0.54 | 0.0005 | |
DGMN | parietal | 0.67 | 0.0004 | 0.59 | 0.0007 | |
temporal | DGMN | 0.66 | 0.0028 | 0.58 | 0.0064 | |
