Table 3 Common CNGs associated with reduced DFS and cancer-specific OS.

CNG (Mb)	p-value^‡		Relevant genes
CNG (Mb)	DFS	OS	Relevant genes
A3 1–31 (n = 8)	0.003	0.002	TPX2, DLGAP4, DSN1, RBL1, FAM83D, MYBL2, PABPC1L, UBE2C, CTSA, MMP9, SULF2, CSE1L, SALL4, ZNF217, PFDN4, AURKA, RAE1, PMEPA1, MYT1^, SLC2A4RG^, ZGPAT^, PTK6^, EEF1A2^, KCNQ2^, CHRNA4^, ARFGAP1^, GATA5, RPS21^, LAMA5^,**, GNAS^, TMEPAI^, ZBP1^, PCK1^, TFAP2C^, CSTF1^, DOK5^, CYP24A1^, BCAS1^, ZNF217^, SRC^
B4 1–29^† (n = 9)	0.001	0.01	KIN^, TAF3^, GATA3^, MCM10, VIM^*, MLLT10, ZEB1^,***
D4 1–16.7 (n = 6)	0.009	0.006	OMD, SYK, PDCD1LG2 (PD-L2), CD274 (PD-L1), JAK2, GLIS3, RFX3, DMRT1, DOCK8, FOXD4
F2 64–82.3^† (n = 8)	0.0002	0.006	EXT1, SAMD12, NOV, TAF2, DCC1, MRPL13, MTBP, SNTB1, HAS2, ZHX2, FBXO32, RNF139, TATDN1, MTSS1, MYC^,, WISP1, NDRG1, ST3GAL1, KHDRBS3, PTK2*

DFS, disease-free survival; OS, cancer-specific overall survival.
^*Breast cancer-associated CNGs^{19,28,41,42,43}.
^**Amplification validated by the cancer gene census in human cancers⁵⁹.
^***EMT-related genes commonly affected by CNGs in multiple cancer types²¹.
^†significant in multivariate analysis, and ^‡univariate analysis log-rank (Mantel-Cox).

Quick links

Search