Table 4 Functional clustering and KEGG pathway analysis of genes in CNGs significantly correlated with poor outcome.
From: Analysis of Copy-Number Variations and Feline Mammary Carcinoma Survival
Biological process | Genes | p-value |
|---|---|---|
KEGG pathway analysis | ||
Endocytosis | ARFGAP1, PARD6B, IL2RA, CHMP4B, RAB22A, PIP5K1B, ASAP1, STAM, ITCH, SRC | 0.003 |
Tight junction | PRKCQ, PARD6B, CSNK2A1, EPB41L1, TJP2, MYH7B, SRC, MYL9 | 0.004 |
Cell adhesion molecules (CAMs) | SIGLEC1, ITGA8, CD274 (PD-L1), CD40, SDC4, CDH4, PDCD1LG2 (PD-L2) | 0.004 |
Pathways in cancer | E2F1, PLCG1, LAMA5, MMP9, BCL2L1, STK4, MYC | 0.04 |
Functional clustering | ||
WAP | WFDC8, PI3, SLPI, WFDC5, WFDC2, WFDC3, WFDC13 | <0.00001 |
Serine protease inhibitor† | WFDC8, SPINT4, PI3, ITIH5, SLPI, ITIH2, WFDC5, WFDC2, WFDC3 | 0.001 |
Protease inhibitor‡ | WFDC8, SPINT4, PI3, SERPINE1, ITIH5, SLPI, ITIH2, R3HDML, WFDC5, WFDC2, WFDC3 | 0.02 |
Serine-type endopeptidase inhibitor activity‡ | WFDC8, SPINT4, PI3, ITIH5, SLPI, ITIH2, WFDC5, WFDC2, WFDC3 | 0.007 |
Enzyme inhibitor activity‡ | WFDC10B, PHACTR3, PKIG, ANXA1, TRIB3, BCL2L1, R3HDML, TRIB1, WFDC13, WFDC8, SPINT4, PI3, SLPI, ITIH5, ITIH2, WFDC5, WFDC2, WFDC3 | 0.004 |
