Table 6 Genes in genomic regions affected by common CNLs that significantly cluster for specific biological processes and KEGG pathways.
From: Analysis of Copy-Number Variations and Feline Mammary Carcinoma Survival
Biological process | Genes | p-value |
|---|---|---|
KEGG pathway analysis | ||
Pyruvate metabolism | LDHC, LDHA, LDHAL6A, DLAT, ACAT1, PDHB | 0.002 |
PPAR signalling pathway | ACOX2, APOA1, ACSL1, ILK, APOA5, APOC3, MMP1 | 0.006 |
N-Glycan biosynthesis | TUSC3, STT3A, DPAGT1, ALG8, ALG9 | 0.006 |
Functional clustering | ||
Cell adhesion† | MPZL3, MPZL2, CADM1, OPCML, CNTN5, INPPL1, CNTN6, DSCAML1, MCAM, DCHS1, NCAM1, CD44, FAT3, HEPACAM, FAT1, ESAM, CNTN4, CNTN3, CHL1, NTM | 0.004 |
Biological adhesion† | MPZL3, MPZL2, CADM1, OPCML, DSCAML1, DCHS1, APOA4, BARX2, FAT3, CD44, FAT1, ILK, ESAM, TECTA, CNTN5, MAGI1, INPPL1, CNTN6, MCAM, THY1, NCAM1, HEPACAM, CDON, CNTN4, CNTN3, CHL1, NTM, FEZ1 | 0.01 |
Proteinaceous extracellular matrix† | TECTA, WNT5A, ADAMTS15, MMP8, MMP27, MMP7, MMP13, MMP1, MMP12, MMP10, ADAMTS9, MMP20, ADAMTS8, CHL1 | 0.05 |
Cell-cell adhesion† | MPZL2, CADM1, DSCAML1, DCHS1, THY1, APOA4, NCAM1, BARX2, FAT3, CD44, FAT1, CNTN4, ESAM | 0.05 |
