Table 7 Functional clustering and KEGG pathway analysis of genes in common CNGs detected in basal-like TN-FMCs.

From: Analysis of Copy-Number Variations and Feline Mammary Carcinoma Survival

Biological process

Genes

p-value

KEGG pathway analysis of genes in CNGs*

 Jak-STAT signalling pathway

IL2RA, IL15RA, JAK2, STAM

0.05

Functional clustering of genes in CNGs*

 Kinase‡

TRPM6, SEPHS1, MYO3A, PFKFB3, AK3, PFKP, PIP5K1B, WNK2, PRKCQ, MAP3K8, CKS2, ROR2, JAK2, MASTL, PIP4K2A, CDK20, SYK, CAMK1D

<0.00001

 Transferase‡

TRPM6, SPTLC1, SEPHS1, MYO3A, PFKFB3, MTPAP, PIP5K1B, AK3, PFKP, WNK2, PDSS1, SUV39H2, NMT2, PRKCQ, NSUN6, ST8SIA6, PTAR1, TRDMT1, MAP3K8, ROR2, JAK2, MASTL, PIP4K2A, CDK20, CAMK1D, SYK

<0.00001

 Serine/threonine-protein kinase†,‡

PRKCQ, TRPM6, MYO3A, MAP3K8, WNK2, MASTL, CDK20, CAMK1D

0.04

 Protein kinase, ATP binding site†

PRKCQ, MYO3A, MAP3K8, ROR2, JAK2, WNK2, MASTL, CDK20, SYK, CAMK1D

0.02

 Protein kinase activity†

PRKCQ, TRPM6, MYO3A, MAP3K8, ROR2, JAK2, WNK2, MASTL, CDK20, SYK, CAMK1D

0.05

 sh3 domain§,‡,#

CACNB2, ABI1, MPP7, STAM, TJP2, NEBL

0.01

  1. *CNGs in FCAs B4 (1–29 Mb) and D4 (1–16.7 Mb).
  2. †GOTERM.
  3. ‡SP_PIR_KEYWORDS.
  4. §UP_SEQ_FEATURE.
  5. #INTERPRO. Data analysed with DAVID Bioinformatics.
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