Figure 3
From: Plasma microRNA levels in male and female children with cystic fibrosis
(A) Table showing experimentally validated targets of miR-885-5p, as retrieved from miRTarBase. Only targets with evidence from more than one publication are listed. (B) Removal of GO term redundancy and semantic visualisation of the significantly associated GO biological processes (adjusted p value < 0.05) using REVIGO. The scatterplot shows the cluster representatives (after redundancy reduction) in a two-dimensional space derived by applying multidimensional scaling to a matrix of the GO terms’ semantic similarities (the axes have no intrinsic meaning). Bubble colour indicates the log10 (adjusted p value); size indicates the frequency of the GO Biological Process terms in the underlying UniProt database (bubbles of more general terms are larger). (C) Schematic summarising RAC1 related pathways by which miR-885-5p may potentially influence CF pathogenesis (dashed lined indicates ‘possible’).
