Table 3 Point mutations in the colistin chromosomal resistance genes of the Klebsiella pneumoniae isolates from South Africa.
Isolate ID | MIC | pmrB | pmrA | phoP | phoQ | kpnE | kpnF | mgrB | ccrB |
|---|---|---|---|---|---|---|---|---|---|
K118 | >4 | A246T, L339C, H340I, N341T, R342D, Q343S, P346Q | — | — | — | K112Q | — | — | Gene not found |
K141 | >4 | — | — | — | — | — | — | — | Gene not found |
K145 | 4 | — | M66I | — | — | L7* | — | — | |
K146 | 4 | — | — | — | — | — | — | — | |
K021 | 4 | — | — | — | S405R, H406Y | — | — | — | |
K031 | 4 | — | — | — | H406Y | — | — | — | |
K053 | 4 | A246T | S64T | — | — | — | — | — | |
K054 | 4 | A246T | S64T | — | — | — | — | — | |
K059 | 4 | A246T | S64T | — | — | — | — | — | |
K085 | 4 | — | A217V | — | — | — | I39F, Del RRKIYGF (40–46) | — | |
K090 | 4 | — | — | — | — | I88M, K107R | Y66T | — | C12Y, A35V, Y36H, G191E, N388D, S379P, W404R |
K038 | ≤2 | — | — | — | — | — | — | — | C12Y, G191E, S379P, 404R, F213L, T248I, Q258R |
K080 | ≤2 | — | — | — | — | — | — | — | |
K077 | ≤2 | — | — | — | — | — | — | — | |
K117 | ≤2 | — | — | — | — | — | — | — | |
K086 | ≤2 | — | — | — | — | — | — | — | |
K061 | ≤2 | — | — | — | — | — | — | — | |
K089 | ≤2 | — | — | — | — | — | — | — |
