Figure 1
From: Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis
Histological characterization of DIO-NASH model – validation of NASH pathology. (A) Representative images of Hematoxylin & Eosin (H&E) and Pico-Sirius Red (PR) stainings, and immunohistochemical stainings of collagen 1a1, α-SMA and galectin-3. (B) Histological assessment of steatosis, inflammation and NALFD activity score (H&E) and fibrosis stage (PR). (C) Quantitative histochemical assessment of liver lipid content (p < 0.001) (H&E), collagen 1a1 (p = 0.042), α-SMA (p < 0.001), galactin-3 positive cells (p < 0.001) (% of fractional area), whole body weight (p < 0.001) and liver weight (p < 0.001). In panel C, data are expressed as the mean of n = 4-5 ± SEM. A student’s t-test was used. *p < 0.05, **p < 0.01, ***p < 0. 001 vs. CHOW.
